Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cdc37 | the chaperone protein associates with the IKK complex and is required for its TNFalpha-induced activation | Mus musculus | |
HSP70 | the chaperone protein associates with the IKK complex and is required for its TNFalpha-induced activation | Mus musculus | |
Hsp90 | the chaperone protein associates with the IKK complex and is required for its TNFalpha-induced activation | Mus musculus | |
additional information | the IkappaB complex gets activated by phosphorylation, the enzyme activity is induced by proinflammatory cytokines and by oxidative and genotoxic stress, mechanisms/pathways of activation and derepression of the IKK complex, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | fibroblasts of ikkbeta-/- mice exhibit enhanced apoptosis in response to TNFalpha, NEMO/IKKgamma-deficient mice shows a phenotype with liver damage, but can be rescued by inactivation of the gene encoding the tumor necrosis factor-1, phenotypes, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | IKKbeta and IKKalpha are almost entirely cytoplasmic, IKK complex component scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, shuttles between the cytoplasm and the nucleus in a CRM-dependent manner | Mus musculus | 5737 | - |
nucleus | IKK complex component scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, shuttles between the cytoplasm and the nucleus in a CRM-dependent manner | Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IkappaB protein | Mus musculus | the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages | ADP + phosphorylated IkappaB | - |
? | |
additional information | Mus musculus | mechanisms/pathways of activation and derepression of the IKK complex, regulation, detailed overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the IkappaB complex gets activated by phosphorylation and then autophosphorylates IkappaBalpha at Ser32 and Ser36 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
RAW-264.7 cell | macrophage cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IkappaB protein | the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages | Mus musculus | ADP + phosphorylated IkappaB | - |
? | |
ATP + IkappaBalpha | phosphorylation of IkappaBalpha at Ser32 and Ser36 | Mus musculus | ADP + phosphorylated IkappaBalpha | - |
? | |
ATP + IkappaBbeta | phosphorylation of IkappaBalpha at Ser19 and Ser23 | Mus musculus | ADP + phosphorylated IkappaBbeta | - |
? | |
additional information | mechanisms/pathways of activation and derepression of the IKK complex, regulation, detailed overview | Mus musculus | ? | - |
? | |
additional information | the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview, the complex contains a zinc finger-like domain, N- and C-terminal coiled-coil domains, two alpha-helices and a leucine zipper | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
IkappaB-kinase | - |
Mus musculus |
IKK | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |